NUCYNTA (Tapentadol): Important Safety Information NUCYNTA (tapentadol) is a prescription-only centrally-acting analgesic used for the management of moderate to severe acute pain. It is a Schedule II controlled substance in the United States due to its potential for abuse, addiction, and serious risks. 1. 🧪 Mechanism of Action Tapentadol has a dual mechanism of action: Mu-opioid receptor agonist (similar to traditional [...]